Natural regulatory T cells inhibit production of cytotoxic molecules in CD8⁺ T cells during low-level Friend retrovirus infection.

Depletion of Tregs resulted in a highly significant expansion of virus-specific CD8 + T cells (Figure 2 A), with a 5-times higher mean frequency of tetramer + CD8 + T cells recognizing the H-2Db-restricted F-MuLV glycosylated gag epitope.

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