Addressing RNA integrity to determine the impact of mitochondrial DNA mutations on brain mitochondrial function with age.

PLoS One · 2014 · PMC4018447 · PMID 24819950

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borderline significantp = 0.07so close (0.05 < p ≤ 0.1)

Mitochondrial DNA from aged brains (18 months) displayed significantly elevated mutagenesis in the Nd3 (+ 40%) and Nd1 (+ 90%) sites and borderline significant (p = 0.07) increase in the 12S site (+ 50%), whereas the Nd5, Nd6, Cytb and CoxI sites were unaffected.

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