AAV-dominant negative tumor necrosis factor (DN-TNF) gene transfer to the striatum does not rescue medium spiny neurons in the YAC128 mouse model of Huntington's disease.

PLoS One · 2014 · PMC4019512 · PMID 24824433

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highly significantno p-value reported

Highly significant increases (over 1000-fold) in IL-8 and IL-6 transcripts and significant increases in TNF (2-fold) in HD patient post-mortem striatal tissue have been reported in independent studies [10] .

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