Induction of protective immune responses against schistosomiasis using functionally active cysteine peptidases.

Front Genet · 2014 · PMC4021144 · PMID 24847355

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highly significantno p-value reported

We have shown that sub-cutaneous injection of recombinant and functionally active Schistosoma mansoni cathepsin B1 (SmCB1), or a cathepsin L from a related parasite Fasciola hepatica (FhCL1), elicits highly significant protection (up to 73%) against an experimental challenge worm infection in murine models of schistosomiasis.

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