Breast cancer risk after radiotherapy for heritable and non-heritable retinoblastoma: a US-UK study.

However, there was a pronounced and significant ( P =0.047) increase in the risk of breast cancer with increasing radiation dose for non-heritable retinoblastoma patients and a slight and borderline significant ( P =0.072) decrease in risk of breast cancer with increasing radiation dose for heritable retinoblastoma patients, implying significant ( P =0.024) heterogeneity in radiation risk between the heritable and non-heritable retinoblastoma groups; this was unaffected by the blindness status.

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The exact regressions of Table 5 were the same, and as the male case was non-heritable and radiation unexposed, the effect of excluding him was to make the SIR in Table 2 for the relevant cell marginally statistically significant (nine cases observed, 4.78 expected, SIR=1.88, 95% CI 0.86, 3.57; results not shown).

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