CD45RA-Foxp3high but not CD45RA+Foxp3low suppressive T regulatory cells increased in the peripheral circulation of patients with head and neck squamous cell carcinoma and correlated with tumor progression.

J Exp Clin Cancer Res · 2014 · PMC4022051 · PMID 24761979

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an elevated trendno p-value reported

However, not all cancer publications report an elevated trend, with some observing no significant difference in the frequency of Tregs in the peripheral circulation of patients and healthy donors, including one study examining oral SCC [ 32 , 33 ].

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