The interplay of DNA methylation over time with Th2 pathway genetic variants on asthma risk and temporal asthma transition.

To take the multiple testing into account while admitting the dependence between tests in this selection process, we set the significance level at a lower level, specifically, 0.01, aiming to identify models with possibly significant CpG sites and SNPs.

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We further hypothesize that association of asthma risk with methylation and with the interaction between DNA methylation and SNP may be significant at one age but absent at another.

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