Effects of glucosamine and risedronate alone or in combination in an experimental rabbit model of osteoarthritis.

Using histomorphometry we could observe that in OA + GS samples the surface undulations (FI) were more elevated than in other treatment groups, but still lower than the OA group; this findings were in conformity with those of other groups who reported that the administration of glucosamine did not prevent fibrillation and/or erosions of the articular cartilage in an ACLT model in rabbits although there was an overall trend toward a reduction in the severity of the disease [ 2 , 5 ].

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