Low abundance of the matrix arm of complex I in mitochondria predicts longevity in mice.

Nat Commun · 2014 · PMC4024759 · PMID 24815183

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highly significantno p-value reported

The increase in the frequency of Sen-β-Gal-positive cells was highly significant ( Fig 6J ), indicating that disturbance of complex I assembly induced premature senescence of normal somatic cells.

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