Detecting differentially methylated loci for multiple treatments based on high-throughput methylation data.

BMC Bioinformatics · 2014 · PMC4026834 · PMID 24884464

Europe PMC DOI

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an increasing trendno p-value reported

If there is an increasing trend over the K treatments, we should use the one-sided p-value, p r , g = Prob ( Z > c g ) = 1 - Φ( c g ).

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a decreasing trendno p-value reported

On the other hand if there is a decreasing trend over the K treatments, we should use the other one-sided p-value, p l , g = Prob ( Z < c g ) = Φ( c g ).

also in 47,180 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.