The PET models are too slow and complex to be physiologically reliable, despite the paucity of assumed parameters.[ 10 ] In 1986, Fox et al .,[ 11 ] using PET radiotracers, found that after a stimulus, the oxygen extraction fraction (OEF) response “uncoupled” and fell by a highly significant 19%, whereas cerebral blood flow (CBF), cerebral blood volume, and cerebral oxygen metabolic rate (CMRO2) were coupled with the stimulus and showed significant increase.
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