We detected a trend towards an increase in the number of granule neurons in Smad3 deficient mice (23.8%) compared with their control littermates (first 500 μm; Smad3 +/+ , 40986 ± 3406; Smad3 -/- , 50797 ± 2823; P = 0.059; Figure 4 F), although this strong trend did not quite reach statistical significance.
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Smad3 is required for the survival of proliferative intermediate progenitor cells in the dentate gyrus of adult mice.
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