Barely Significant
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Genome-wide quantitative analysis of histone H3 lysine 4 trimethylation in wild house mouse liver: environmental change causes epigenetic plasticity.

PLoS One · 2014 · PMC4029994 · PMID 24849289

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The sentences

highly significantP <2.2*10 −16actually significant
This shift was highly significant as determined by the Mann-Whitney-Wilcoxon Test ( P <2.2*10 −16 ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.