The effects of ketamine and risperidone on eye movement control in healthy volunteers.

As hypothesised, a highly significant effect of ketamine was observed for both measures of SPEM performance, indicating a slowing of the eye in the pursuit of the target and higher saccadic frequencies. 20 , 22 However, ketamine did not have any main effects on the AS error rate, a performance measure known to be substantially impaireded in schizophrenia. 13 Ketamine also did not have any effects on other saccadic measures such as latency, gain or velocity.

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