Anabolic Actions of the Regenerative Agent Enamel Matrix Derivative (EMD) in Oral Periosteal Fibroblasts and MG 63 Osteoblasts, Modulation by Nicotine and Glutathione in a Redox Environment.

An increasing trend was seen for the metabolite 4-A, up to E60 and a slight dip at E70; DHT being the principal physiologically active metabolite, we established that EMD was optimally effective at a concentration of 30 μg/mL; this concentration was used for subsequent experiments.

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