Patient freedom to choose a weight loss diet in the treatment of overweight and obesity: a randomized dietary intervention in type 2 diabetes and pre-diabetes.

In a secondary analysis of the intention-to-treat weight loss data with last measured weight carried forward gave a highly significant diet group by time by gender interaction (p = 0.002) with men doing better in the No Choice group overall (maximum difference “No Choice “-2.9 ± 4.6 kg vs. “Choice”-6.2 kg ± 5.3 kg at 6 months) and women doing better in the Choice group overall (maximum difference Choice -3.1 ± 3.7 kg vs. “No Choice” -2.0 kg ± 2.6 kg at 6 months).

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Change in body weight at 12 months (relative to baseline) was borderline significant (p = 0.07) when comparing subjects who had no diabetes medication changes (-2.4 kg weight change), diabetes medication reductions (-4.4 kg) or increases (1.8 kg).

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