a decreasing trendP =0.097
However, there was a decreasing trend in the mean forelimb grip strength observed in the 129SVE knockout animals compared with their wild-type and heterozygous littermates (F 2,51 =2.71, P =0.097; mean grip strength: WT: 127.86±2.87 g; Het: 128.84±2.13 g; KO: 119.72±3.46 g).