None of the top 15 genes had previously been associated with OIH, as determined by a search of the PubMed database (using the gene name and “opioid-induced hyperalgesia” or “opioid” or “morphine.”) Although these 15 genes all had highly significant statistical correlations with mechanical OIH, it was difficult to determine which was most likely to be a causative genetic factor.
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The Netrin-1 receptor DCC is a regulator of maladaptive responses to chronic morphine administration.
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