Fanca deficiency reduces A/T transitions in somatic hypermutation and alters class switch recombination junctions in mouse B cells.

J Exp Med · 2014 · PMC4042646 · PMID 24799500

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highly significantP < 10 −5actually significant

However, supporting a direct, specific role for Fanca during SHM, we observed that the frequency of mutations at A/T residues was significantly reduced in Fanca −/− mice (P = 10 −4 ; Table 1 ), and this reduction was associated with a highly significant (P < 10 −5 ) decrease in the frequency of transitions at these sites ( Table 1 ).

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