2) Evidence from GO term enrichment analysis Go terms “synaptic membrane” (GO:0097060), “synaptic transmission” (GO:0007268), “transmission of nerve impulse” (GO:0019226) and “multicellular organismal signaling” (GO:0035637) are barely significantly enriched in found SNPs pairs ( Table 6 ). 3) Evidence from public database and literatures We found multiple-SNP genotype patterns inside individual genes (8 out of 18 genes in Table S2 are related with mental disorder).
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AprioriGWAS, a new pattern mining strategy for detecting genetic variants associated with disease through interaction effects.
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