β-adrenergic receptor-dependent alterations in murine cardiac transcript expression are differentially regulated by gefitinib in vivo.

PLoS One · 2014 · PMC4047088 · PMID 24901703

Europe PMC DOI

hedged sentence

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closest p · 0.0× alpha

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highly significantp-value = 2.52E-15actually significant

Indeed, the upstream regulator with the most highly significant association with the ISO-regulated gene cohort was determined through Ingenuity analysis to be CREB (p-value = 2.52E-15; z-score for activation = 4.157), confirming that transcriptome analysis of the cardiac RNA samples detected predicted and experimentally observed responses to ISO stimulation.

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