Evaluation of Various Factors Affecting Bioconversion of l-Tyrosine to l-DOPA by Yeast Yarrowia lipolytica-NCIM 3450 Using Response Surface Methodology.

The ANOVA of the quadratic regression model (Table 2 ) demonstrated that Eq. ( 1 ) is a highly significant model ( P = 0.001).

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Also the values of pH (X 1 ), yeast extract (X 3 ), l -tyrosine (X 7 ), and CuSO 4 (X 8 ) were above the t value limit that implies that these factors are possibly significant.

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