Although the difference in high and normal glucose did not achieve significance, hypermethylated promoter patterns show that β2-adrenergic receptor gene is silenced in retinal endothelial cells possibly due to hypermethylation of its promoter (Figure 4 D, E and F).
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Differential expression and role of hyperglycemia induced oxidative stress in epigenetic regulation of β1, β2 and β3-adrenergic receptors in retinal endothelial cells.
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