Caffeine interaction with glutamate receptor gene GRIN2A: Parkinson's disease in Swedish population.

Caffeine intake of 200–≤400 mg/day was associated with 58% risk reduction (OR = 0.42, 95%CI = [0.25–0.69], p<0.001), and that of 400 mg–≤600 mg/day was associated with a highly significant 80% reduction (OR = 0.20, 95%CI = [0.08–0.51], p<0.001), and >600 mg/day had also strong 79% reduction (OR = 0.21, 95%CI = [0.09–0.52], p<0.001) comparing to the lowest caffeine intake group with 0–≤200 mg/day.

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Interestingly, when rare heterogeneous TT genotype was excluded from the analysis, among the light caffeine consumers, there was a near significance that TC is more PD protective than CC (OR = 0.42, 95%CI = [0.17–1.03], p = 0.06), while in the heavy caffeine consumers, this trend was weaker (OR = 0.69, 95%CI = [0.40–1.17], p = 0.16).

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