A BRCA1 deficient-like signature is enriched in breast cancer brain metastases and predicts DNA damage-induced poly (ADP-ribose) polymerase inhibitor sensitivity.

As originally hypothesized, there is a highly significant correlation (R 2 = 0.77; P value 0.00017) of the BD-L metagene with pharmacological response of cell lines to the combined administration of olaparib and temozolomide (Figure 4 A, lower panel).

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