The RNA-binding protein hnRNPLL induces a T cell alternative splicing program delineated by differential intron retention in polyadenylated RNA.

When compared with annotated alternative exons in the Ensembl mouse gene set [ 26 ] (NCBIM37, Ensembl release 67), this list showed a highly significant, non-random overlap with the alternative splicing categories of cassette exons, mutually exclusive exons and intron retention (according to the nomenclature of [ 27 ]) whereas constitutive exons were found significantly less than expected (permutation P -value = 0.001; Figure 4 , Table 1 ).

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