Therefore, a few questions arise: Are the resistant clones still able to undergo ferroptosis in response to different inducers? Does modulation of AKR1C expression by RNAi re-establish sensitivity to erastin? 7) In previous work (Yagoda 2007), the authors showed that erastin bound to SLC7A5, a subunit of system L, and they mention in Dixon 2012 that treatment with erastin resulted in highly significant decreases in the levels of system L substrates.
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Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis.
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