PU.1 target genes undergo Tet2-coupled demethylation and DNMT3b-mediated methylation in monocyte-to-osteoclast differentiation.

Genome Biol · 2013 · PMC4054781 · PMID 24028770

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In the case of hypermethylated genes, we also found highly significant enrichment of signal transduction (FDR = 4.09E-17), and enrichment of categories related to other hematopoietic cell types, suggesting that hypermethylation and associated silencing take place in gene sets that become silent in differentiated OCs (Figure 1 D).

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