Performance on a pattern separation task by Alzheimer's patients shows possible links between disrupted dentate gyrus activity and apolipoprotein E ∈4 status and cerebrospinal fluid amyloid-β42 levels.

Comparisons to controls There were highly significant differences on the task for the ability to correctly identify the original pictures (F(1,301) = 124.4, P <0.0001) and the ability to identify the closely similar pictures (F(1,301) = 68.4, P <0.0001).

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