a nonsignificant trendp = 0.06
21.7±0.4 gm p = 0.3) While there was a nonsignificant trend toward increased weight in WT male mice treated with estradiol (1.6±0.7 gm, p = 0.06), estradiol treatment was associated with significantly greater pre-CA/CPR weight than vehicle treatment in male GPR30KO mice (GPR30KO-EST 27.8±0.5 gm, GPR30KO-VEH 25.7±0.4 gm, p = 0.004).