Certain adenylated non-coding RNAs, including 5' leader sequences of primary microRNA transcripts, accumulate in mouse cells following depletion of the RNA helicase MTR4.

While we were able to detect adenylated 5′ leader sequences corresponding to over 100 miRNAs in the mMtr4 knockdown, only a handful of these accumulate to highly significant levels ( Table 3 , Fig. 6 , and Table S3 ).

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