All combinations with mirincamycin were additive with a slight trend to synergism, with an overall geometric mean fractional inhibitory concentration at 50% inhibition (FIC 50 ) of 0.78, 0.80 and 0.80 for TQ, DHA, and CQ, respectively.
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Mirincamycin, an old candidate for malaria combination treatment and prophylaxis in the 21st century: in vitro interaction profiles with potential partner drugs in continuous culture and field isolates.
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