Gut-directed hypnotherapy in children with irritable bowel syndrome or functional abdominal pain (syndrome): a randomized controlled trial on self exercises at home using CD versus individual therapy by qualified therapists.

BMC Pediatr · 2014 · PMC4060754 · PMID 24894077

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likely to be significantno p-value reported

The exact costs of treatment of these children are not known, but are also likely to be significant since treatment of adult patients with IBS costs more than $20 billion per year [ 8 , 9 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.