Despite this variability, we found highly significant hypermethylation in tumor in respect to matched normal breast tissue for all the analyzed CpGs (paired t-test, p-value ranging from 7.97 × 10 −12 to 0.017 depending on the CpG unit; Figure 2 C).
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The nucleolar size is associated to the methylation status of ribosomal DNA in breast carcinomas.
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