FAP-α (Fibroblast activation protein-α) is involved in the control of human breast cancer cell line growth and motility via the FAK pathway.

When we examined any effect on cell adhesion to basement membrane, it was seen that MCF7exp cells exhibited lower adhesion but that MDA-MB-231exp cells were more adhesive compared with those of the wild type and control cells, although this did not achieve significance (MCF7wt, MCF7pef, MCF7exp, MDA-MB-231wt, MDA-MB-231pef, and MDA-MB-231exp cells were 31.3 ± 20.6, 24.3 ± 12.4, 26.7 ± 31.5, 12.7 ± 18.8, 15.5 ± 15.6, and 14.0 ± 14.4 respectively, P > 0.05) (Figure 4 B).

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