Transcriptomic evidence for immaturity of the prefrontal cortex in patients with schizophrenia.

Similarity between the olanzapine-treated rodent PFC and the human developing MFC was weakly but marginally significant after Bonferroni correction (significance level of P < 0.0125; Additional file 5 : Figure S4o; see the Methods section and Additional file 1 : Table S27), suggesting that olanzapine may have some effect on the induction of juvenile-like gene expression in adult PFC.

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Regarding gene expression, our bioinformatics analyses revealed highly significant similarities in the relative gene expression patterns in the PFC between patients with schizophrenia (as compared to healthy controls) and infants (as compared to adults).

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