DDX6 regulates sequestered nuclear CUG-expanded DMPK-mRNA in dystrophia myotonica type 1.

Nucleic Acids Res · 2014 · PMC4066779 · PMID 24792155

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highly significantP < 0.001actually significant

Interestingly, we found a highly significant ( P < 0.001) increase in nuclear CUG-foci frequency in DM1 fibroblasts derived from two different patients (DM1 and DM1′) upon knockdown of DDX6 (foci elevated from 4.4 ± 0.28 and 7.9 ± 0.34 foci per cell respectively, to 7.1 ± 0.48 and 9.7 ± 0.37 per cell, respectively) (Figure 2A and quantified in Figure 2D ).

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