Sylamer analysis ( van Dongen et al., 2008 ) of microarray data, from WT and miR-142 −/− FL-derived MKs, uncovered a highly significant enrichment for the 7- and 8-mer seeds of miR-142-3p among genes that were up-regulated in miR-142 −/− MKs (Blue lines; Figure 5B ).
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miR-142 orchestrates a network of actin cytoskeleton regulators during megakaryopoiesis.
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