A further meta-analysis of the subgroup of 3 studies that included nonsmoking populations or populations with low prevalence of smoking showed an increased risk for the earliest versus the median menarcheal age group with borderline significance (pooled HR = 1.24, 95% CI: 1.00, 1.55) and slightly reduced heterogeneity ( I 2 = 47.8%).
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Age at menarche and risks of all-cause and cardiovascular death: a systematic review and meta-analysis.
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