In this respect it might be significant that rosiglitazone-induced myocardial hypertrophy, an early hallmark and important risk factor for the development of heart failure [ 9 ], still occurs in cardiomyocyte-specific PPARγ knock-out mice [ 10 ].
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A systems biology approach to understand the pathophysiological mechanisms of cardiac pathological hypertrophy associated with rosiglitazone.
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