Twenty-four hour quantitative-EEG and in-vivo glutamate biosensor detects activity and circadian rhythm dependent biomarkers of pathogenesis in Mecp2 null mice.

There was a highly significant correlation between glutamate loads and wake durations in both WT and KO mice [ r = 0.65 and 0.75 respectively, and p (2 tailed) < 0.0001 for both genotypes].

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