borderline significantp = 0.067
Although the reduced survival of K5-Cre+ Dicer c/c mice with a single conditional allele of p53 is borderline significant (p = 0.067), ablation of both functional alleles of p53 greatly reduced survival of Dicer-ablated mice relative to Dicer-ablated, p53-wildtype (p = 0.0001) or Dicer-ablated, p53-haploinsufficient (p = 0.0002) mice.