Since no heterogeneity between study-specific effects was observed, the fixed-effect model was conducted in all genetic models except for recessive and heterozygous comparisons, which showed significant heterogeneity ( P <0.1) When the data from all eligible studies, with a total of 4,302 NTDs cases and 4,238 controls, were pooled together, a borderline significant overall association was found under four genetic models (A allele vs.
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Association between MTHFD1 G1958A polymorphism and neural tube defects susceptibility: a meta-analysis.
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