Spexin is a novel human peptide that reduces adipocyte uptake of long chain fatty acids and causes weight loss in rodents with diet-induced obesity.

The mRNA for Ch12, ORF39 (Spexin) demonstrated a highly significant 14.9-fold drop in expression in obese compared to non-obese fat tissues ( Figure 1B ), the largest change in gene expression observed in obese human fat (p=0.00292).

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