In patients with TLE and abnormal hippocampal MRI scans, Kimiwada showed an increasing trend in the MD values for the thalami ipsilateral to the epileptic focus, and Keller showed changes in the mean FA values of the bilateral thalamus and putamen [ 12 , 29 ].
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Evaluation of subcortical grey matter abnormalities in patients with MRI-negative cortical epilepsy determined through structural and tensor magnetic resonance imaging.
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The clinical-MD correlations with epilepsy duration showed a positive trend, but only that for the left putamen reached statistical significance ( r = 0.428, p = 0.047) (Figure 3 D).