Developmental programming by high fructose decreases phosphorylation efficiency in aging offspring brain mitochondria, correlating with enhanced UCP5 expression.

However, we observed a tendency ( P = 0.09) toward an increase in UCP5 mRNA levels in the fructose offspring compared with control, and interestingly, we found a highly significant inverse correlation between UCP5 mRNA levels and the P/O 2 ratio ( P = 0.008) ( Figure 2B ).

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It may be argued that such a small change, in spite of being statistically significant, may not be significant in terms of brain function, and this aspect needs to be examined further.

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