The results showed that the significance level decreased as the disease prevalence increased (Table 6 ), but all joint association remained at least marginally significant with the disease prevalence of 0.29 ( p -values were 4.08e-12, 0.054 and 2.00e-03 in FSCA, COGA and COGEND, respectively).
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A non-parametric approach for detecting gene-gene interactions associated with age-at-onset outcomes.
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