Dolutegravir in antiretroviral-experienced patients with raltegravir- and/or elvitegravir-resistant HIV-1: 24-week results of the phase III VIKING-3 study.

Increased activity score of the failing background regimen did not improve response; the change from baseline was actually reduced in those with a PSS of 2 or >2 compared with those with a score of 0. Baseline INI resistance (genotypic or phenotypic) and viral load were highly significant predictors for week 24 response: for every 2-fold increase in DTG FC, the odds of achieving HIV-1 RNA <50 c/mL were 63% lower; the odds of achieving this endpoint were 96% lower in subjects with virus harboring Q148 + ≥2 mutations compared with the response in those with no evidence of Q148 mutations (Table 4 ).

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