In the inflammatory autoimmune disease scleroderma (systemic sclerosis), HCMV appears to accelerate the development of disparate disease pathologies 24 - 26 and, of particular importance, we have found a highly significant association between anti-HCMV IgG antibody responses and the GM 3 and GM 17 alleles expressed on IgG1 in these patients. 27 Similar studies evaluating correlations between the presence of particular GM allelic variants and HCMV antibodies should be conducted for glioma patients.
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