Predictive testing for inherited prion disease: report of 22 years experience.

Although this may represent an increasing trend, particularly from around the year 2000 (Pearson's correlation for annual number of predictive tests 1990–2011 vs duration since 1990: P <0.001), it is also possible that the predictive test number may have plateaued since 2005, with the annual number of tests between 2005 and 2011 fluctuating around an average of 11/year (range 9–14).

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Although this proportion is marginally statistically significant compared with an expectation of 50% abnormal ( P =0.03, binomial test), this analysis does not take into account the fact that individuals present for predictive testing having lived through part of the risk period.

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